Peppermint oil has been used to soothe the gastrointestinal tract for hundreds of years. Mahajan, Barbara Kaplan, in Pediatric Gastrointestinal and Liver Disease (Fourth Edition), 2011 Peppermint Oil 214 The usual dose of peppermint oil is 180 to 200 mg 3 times a day 30 minutes before meals AEs include heartburn, perianal burning, and rarely interstitial nephritis. 212 A novel formulation, designed for sustained release in the small intestine, is available for use in the USA. Peppermint oil is also efficacious for global symptoms and abdominal pain, and is usually well tolerated the NNT is 3 (see Table 122.3). Non-anticholinergic antispasmodics that appear to be efficacious include otilonium and certain selective calcium channel blockers (e.g., pinaverium). Moreover, only anticholinergic antispasmodic agents are available in the USA. 212 Overall, there was an improvement of abdominal pain and global symptoms in the pooled analyses however, the quality of most trials was low, results were heterogeneous, and publication bias could not be excluded. Mark Feldman MD, in Sleisenger and Fordtran's Gastrointestinal and Liver Disease, 2021 Anticholinergic and Antispasmodic AgentsĪ meta-analysis of RCTs concluded that antispasmodics were superior to placebo in the treatment of IBS ( Table 122.3), with an NNT of 5. Effects of stressful life events on bowel symptoms: Subjects with irritable bowel syndrome compared with subjects without bowel dysfunction. The British Journal of Clinical Practice, 40, 276–278. A general practice study to compare alverine citrate with mebeverine hydrochloride in the treatment of irritable bowel syndrome. Treatment of irritable bowel syndrome with lorazepam, hyoscine butylbromide and ispaghula husk. Alimentary Pharmacology & Therapeutics, 15, 355–361. Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome. Poynard, T., Regimbeau, C., & Benhamou, Y. Cochrane Database System Review, (1), CD011497. Physical activity for treatment of irritable bowel syndrome. Irritable bowel syndrome: Diagnosis and management. Cochrane Database System Review, (1), CD006442.Īgrawal, A., & Whorwell, P.
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